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$10 Co-Pay Offer

Pay as little as $10 for up to a 90-day supply of ENTRESTO with a Co-Pay Offer, if you’re eligible. Let’s find out!


30-Day Free Trial Offer

To help you get off to a good start with ENTRESTO. This one-time offer is available to all patients when initiating treatment.


Must be 18 or older to receive the ENSPIRE Program from ENTRESTO.

Terms and Conditions apply. See card for more details.

Do you have limited or no prescription coverage?

If you are uninsured or otherwise cannot afford the cost of a Novartis medication, you may be eligible to receive it for free through the Novartis Patient Assistance Foundation (NPAF).

To apply, call NPAF at 1-800-277-2254 or visit the NPAF enrollment website.

Looking for help?

The ENTRESTO support team is here for you Monday-Friday, excluding holidays, 8:00 AM-8:00 PM ET at 1-888-ENTRESTO (1-888-368-7378).


What is the most important information I should know about ENTRESTO?

ENTRESTO can harm or cause death to your unborn baby. Talk to your doctor about other ways to treat heart failure if you plan to become pregnant. If you get pregnant during treatment with ENTRESTO, tell your doctor right away.

Do not take ENTRESTO if you:

  • are allergic to any of the ingredients in ENTRESTO
  • have had an allergic reaction including swelling of your face, lips, tongue, throat (angioedema) or trouble breathing while taking a type of medicine called an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB)
  • take an ACE inhibitor medicine. Do not take ENTRESTO for at least 36 hours before or after you take an ACE inhibitor medicine. Talk with your doctor or pharmacist before taking ENTRESTO if you are not sure if you take an ACE inhibitor medicine
  • have diabetes and take a medicine that contains aliskiren

Before taking ENTRESTO tell your doctor about all of your medical conditions, including if you:

  • have a history of hereditary angioedema
  • have kidney or liver problems
  • are pregnant or plan to become pregnant; are breastfeeding or plan to breastfeed. You should either take ENTRESTO or breastfeed. You should not do both

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take potassium supplements or a salt substitute; nonsteroidal anti-inflammatory drugs (NSAIDs); lithium; or other medicines for high blood pressure or heart problems such as an ACE inhibitor, ARB, or aliskiren.

What are the possible side effects of ENTRESTO?
ENTRESTO may cause serious side effects including:

  • Swelling of your face, lips, tongue and throat (angioedema) that may cause trouble breathing and death. Get emergency medical help right away if you have symptoms of angioedema or trouble breathing. Do not take ENTRESTO again if you have had angioedema while taking ENTRESTO
  • People who are Black or who have had angioedema and take ENTRESTO may have a higher risk of having angioedema
  • low blood pressure (hypotension), which may be more common if you take water pills. Call your doctor if you become dizzy or lightheaded, or you develop extreme fatigue
  • kidney problems
  • increased amount of potassium in your blood (hyperkalemia)

The most common side effects were low blood pressure, high potassium, cough, dizziness, and kidney problems.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.



ENTRESTO is a prescription medicine used to treat adults with long-lasting (chronic) heart failure to help reduce the risk of death and hospitalization. ENTRESTO works better when the heart cannot pump a normal amount of blood to the body.

This information is not comprehensive. Please see full Prescribing Information, including Boxed WARNING, and Patient Prescribing Information.